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Antigen specificity and cross-reactivity drive functionally diverse anti-Aspergillus fumigatus T cell responses in cystic fibrosis
BACKGROUND. The fungus Aspergillus fumigatus causes a variety of clinical phenotypes in patients with cystic fibrosis (pwCF). T-helper …
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A tRNA modifying enzyme as a tunable regulatory nexus for bacterial stress responses and virulence
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Candida albicans Induces Cross-Kingdom miRNA Trafficking in Human Monocytes To Promote Fungal Growth
In response to infections, human immune cells release extracellular vesicles (EVs) that carry a situationally adapted cocktail of …
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PLB-985 Neutrophil-Like Cells as a Model To Study Aspergillus fumigatus Pathogenesis
Fungal infections remain a major global concern. Emerging fungal pathogens and increasing rates of resistance mean that additional …
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RNA-based therapeutics to treat human fungal infections
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Host-derived extracellular vesicles for antimicrobial defense
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Biotinylated surfome profiling identifies potential biomarkers for diagnosis and therapy of Aspergillus fumigatus infection
Aspergillus fumigatus is one of the most common airborne molds capable of causing mycoses and allergies in humans. During infection, …
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Functional surface proteomic profiling reveals the host heat‐shock protein A8 as a mediator of Lichtheimia corymbifera recognition by murine alveolar macrophages
Mucormycosis is an emergent, fatal fungal infection of humans and warm‐blooded animals caused by species of the order Mucorales. Immune …
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Human neutrophils produce antifungal extracellular vesicles against Aspergillus fumigatus
Polymorphonuclear granulocytes (PMNs) are indispensable for controlling life-threatening fungal infections. In addition to various …
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Dynamic Surface Proteomes of Allergenic Fungal Conidia
Fungal spores and hyphal fragments play an important role as allergens in respiratory diseases. In this study, we performed trypsin …
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