Source Themes

Host-derived extracellular vesicles for antimicrobial defense

Biotinylated surfome profiling identifies potential biomarkers for diagnosis and therapy of Aspergillus fumigatus infection

_Aspergillus fumigatus_ is one of the most common airborne molds capable of causing mycoses and allergies in humans. During infection, fungal surface proteins mediate the first contact with the human immune system to evade immune responses or to …

Functional surface proteomic profiling reveals the host heat‐shock protein A8 as a mediator of Lichtheimia corymbifera recognition by murine alveolar macrophages

Mucormycosis is an emergent, fatal fungal infection of humans and warm‐blooded animals caused by species of the order Mucorales. Immune cells of the innate immune system serve as the first line of defense against inhaled spores. Alveolar macrophages …

Human neutrophils produce antifungal extracellular vesicles against Aspergillus fumigatus

Polymorphonuclear granulocytes (PMNs) are indispensable for controlling life-threatening fungal infections. In addition to various effector mechanisms, PMNs also produce extracellular vesicles (EVs). Their contribution to antifungal defense has …

Dynamic Surface Proteomes of Allergenic Fungal Conidia

Fungal spores and hyphal fragments play an important role as allergens in respiratory diseases. In this study, we performed trypsin shaving and secretome analyses to identify the surface-exposed proteins and secreted/shed proteins of *Aspergillus …

Conidial surface proteins at the interface of fungal infection

Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans

Th17 cells provide protection at barrier tissues but may also contribute to immune pathology. The relevance and induction mechanisms of pathologic Th17 responses in humans are poorly understood. Here, we identify the mucocutaneous pathobiont _Candida …

Proteome Analysis Reveals the Conidial Surface Protein CcpA Essential for Virulence of the Pathogenic Fungus Aspergillus

_Aspergillus fumigatus_ is a common airborne fungal pathogen of humans and a significant source of mortality in immunocompromised individuals. Here, we provide the most extensive cell wall proteome profiling to date of _A. fumigatus_ resting conidia, …

UV-Raman Spectroscopic Identification of Fungal Spores Important for Respiratory Diseases

Fungal spores are one of several environmental factors responsible for causing respiratory diseases like asthma, chronic obstructive pulmonary disease (COPD), and aspergillosis. These spores also are able to trigger exacerbations during chronic forms …

Repeated treatments with Chitosan in combination with antibiotics completely eradicate uropathogenic Escherichia coli from infected mouse urinary bladders

Uropathogenic _Escherichia coli_ (UPEC), the primary causative agents of urinary tract infections, colonize and invade the epithelial cells of the bladder urothelium. Infection of immature urothelial cells can result in the formation of persistent …