Source Themes

RNA:DNA triplexes: a mechanism for epigenetic communication between hosts and microbes?
Molecular communication between host and microbe is mediated by the transfer of many different classes of macromolecules. Recently, the …
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RNA as a mediator of host-fungal pathogenesis
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Elucidation of the Aspergillus fumigatus tRNA-derived RNA repertoire from conidia and mycelium
Aspergillus fumigatus is a ubiquitous filamentous fungus that causes devastating infections in severely immunocompromised individuals …
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Secretion of the fungal toxin candidalysin is dependent on conserved precursor peptide sequences
The opportunistic fungal pathogen Candida albicans damages host cells via its peptide toxin, candidalysin. Before secretion, …
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Mod5 mediates a molecular trade-off between optimal gene expression and antifungal resistance.
Increasing antifungal drug resistance is a major concern associated with human fungal infections. Genetic mutation and epimutation …
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RNA-based sensitive fungal pathogen detection
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Disruption of the Aspergillus fumigatus RNA inteference machinery alters the conidial transcriptome.
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Antigen specificity and cross-reactivity drive functionally diverse anti-Aspergillus fumigatus T cell responses in cystic fibrosis
BACKGROUND. The fungus Aspergillus fumigatus causes a variety of clinical phenotypes in patients with cystic fibrosis (pwCF). T-helper …
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A tRNA modifying enzyme as a tunable regulatory nexus for bacterial stress responses and virulence
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Candida albicans Induces Cross-Kingdom miRNA Trafficking in Human Monocytes To Promote Fungal Growth
In response to infections, human immune cells release extracellular vesicles (EVs) that carry a situationally adapted cocktail of …
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