Journal article

tRNA hypomodification facilitates 5-fluorocytosine resistance via cross-pathway control system activation in Aspergillus fumigatus.
Increasing antifungal drug resistance is a major concern associated with human fungal pathogens like Aspergillus fumigatus. Genetic …
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Past, Present, and Future of RNA Modifications in Infectious Disease Research
In early 2024, the National Academies of Sciences, Engineering, and Medicine (NASEM) released a roadmap for the future of research into …
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Tracking the uptake of labelled host-derived extracellular vesicles by the human fungal pathogen Aspergillus fumigatus
Extracellular vesicles (EVs) have gained attention as facilitators of intercellular as well as interkingdom communication during …
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RNA:DNA triplexes: a mechanism for epigenetic communication between hosts and microbes?
Molecular communication between host and microbe is mediated by the transfer of many different classes of macromolecules. Recently, the …
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Secretion of the fungal toxin candidalysin is dependent on conserved precursor peptide sequences
The opportunistic fungal pathogen Candida albicans damages host cells via its peptide toxin, candidalysin. Before secretion, …
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Disruption of the Aspergillus fumigatus RNA inteference machinery alters the conidial transcriptome.
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Antigen specificity and cross-reactivity drive functionally diverse anti-Aspergillus fumigatus T cell responses in cystic fibrosis
BACKGROUND. The fungus Aspergillus fumigatus causes a variety of clinical phenotypes in patients with cystic fibrosis (pwCF). T-helper …
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A tRNA modifying enzyme as a tunable regulatory nexus for bacterial stress responses and virulence
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Candida albicans Induces Cross-Kingdom miRNA Trafficking in Human Monocytes To Promote Fungal Growth
In response to infections, human immune cells release extracellular vesicles (EVs) that carry a situationally adapted cocktail of …
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RNA-based therapeutics to treat human fungal infections
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